550 domain of forward path is not allowed- Trendmicro IMSS

Error: Answered550 domain of forward path is not allowed
A NDR is received as soon as a mail is sent  to external recipients from a SMTP account configured in Outlook

Cause:
Spam Policies misconfigured or relay servers ip address not added in SMTP ROUTING-> Connections section in IMSS

Resolution:

1. Disable the Default SPAM Policy in IMSS and then selectively enable/disable the settings as required.
2. Add the required IMSS Connection settings

More details can be found from the issue faced below:
http://social.technet.microsoft.com/Forums/en-US/exchange2010/thread/c318a20b-5769-4a06-86fd-59d0e6e1533b


 

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